Two of the AFC’s hottest teams collide in Los Angeles as the Indianapolis Colts (5–1) visit the Los Angeles Chargers (4–2) at SoFi Stadium in Week 7. The Colts lead the AFC South behind a balanced offense and a defense that has forced timely turnovers, while the Chargers are riding momentum after a narrow win over Miami. This matchup carries early playoff implications, with both teams looking to solidify their positions in a crowded AFC race. The Chargers have historically had the upper hand in this series, winning four of the last five meetings, but Indianapolis enters with one of the league’s most efficient rushing attacks led by Jonathan Taylor.
How to Watch: Date, Time, Venue, TV
- Date: Sunday, October 19, 2025
- Kickoff Time: 4:05 p.m. ET (1:05 p.m. PT local)
- Venue: SoFi Stadium, Inglewood, CA
- TV Channel (U.S.): CBS
- Streaming Options: NFL+, FuboTV, YouTube TV, Hulu + Live TV, Sling TV, DAZN
- International Broadcast: Sky Sports NFL (UK)
Game Analysis / Preview / Predictions
Quarterback play will headline this matchup. Colts starter Daniel Jones has completed 129 of 180 passes for 1,502 yards with 8 touchdowns and 3 interceptions, boasting a 71.7 percent completion rate. Chargers quarterback Justin Herbert has been equally sharp, throwing for 1,493 yards with 10 touchdowns and 4 interceptions at a 67.6 percent clip.
Skill players will be pivotal. Jonathan Taylor leads the NFL in rushing with 603 yards and 7 touchdowns, giving Indianapolis a reliable ground game. Tight end Theo Johnson has added 370 receiving yards. For Los Angeles, rookie running back Omarion Hampton is sidelined, but depth options like Kimani Vidal stepped up with 124 yards last week. Wideout Quentin Johnston, tied for the team lead with 4 touchdowns, is questionable with a hamstring injury, leaving Ladd McConkey (100 yards and a score vs. Miami) as a key target.
Defensively, both teams bring pressure. The Colts have 16 sacks and 7 interceptions, ranking top five in turnover differential (+5). The Chargers counter with 16 sacks of their own, led by Tuli Tuipulotu, and a secondary anchored by Derwin James.
Coaching tendencies could decide the outcome. Shane Steichen’s Colts average 32.3 points per game, tops in the league, while Jim Harbaugh’s Chargers emphasize balance and late-game execution. Travel fatigue is minimal for Indianapolis, but SoFi’s crowd and the Chargers’ pass rush could test Jones.
If Taylor controls the ground game and Jones avoids turnovers, Indianapolis has the edge. But if Herbert continues his efficient play and the Chargers’ defense disrupts the Colts’ rhythm, Los Angeles could defend home turf in a potential playoff preview.